Journal article
Visual function tests as potential biomarkers in age-related macular degeneration
PN Dimitrov, LD Robman, M Varsamidis, KZ Aung, GA Makeyeva, RH Guymer, AJ Vingrys
Investigative Ophthalmology and Visual Science | Published : 2011
DOI: 10.1167/iovs.10-7043
Abstract
Purpose. To evaluate the potential of psychophysical assessments of retinal function to provide diagnostic biomarkers of early age-related macular degeneration (AMD). Methods. Unilateral visual function was assessed in 221 participants (72.86 ± 9.94 years; 67% women) with early AMD (visual acuity better than 20/60) and 109 controls (73.07 ± 10.32 years; 65% women). Psychophysical assessment included steady state thresholds (4- and 14-Hz flicker and red and blue color) and dynamic tests (photostress recovery [PSR] and dark adaptation [DA]). All test parameters were compared in terms of their diagnostic capacity (sensitivity and specificity), reproducibility, and clinical applicability (test d..
View full abstractGrants
Awarded by NHMRC (National Health and Medical Research Council)
Awarded by Australian Research Council
Funding Acknowledgements
Supported by NHMRC (National Health and Medical Research Council) Project Grant 350224 (RHG, AJV), Australian Research Council Linkage Project ARC-LP0211474, NHMRC CCRE, an NHMRC Career Development Award (RHG), an NHMRC Practitioner Fellowship (RHG), an RVEEH Wagstaff Fellowship (LR), the RVEEH Research Committee, and the Macular Vision Loss Support Society of Australia. CERA receives Operational Infrastructure Support from the Victorian Government.